Endogenous Myc maintains the tumor microenvironment

The ubiquitous deregulation of Myc in human cancers makes it an intriguing therapeutic target, a notion supported by recent studies in Ras-driven lung tumors showing that inhibiting endogenous Myc triggers ubiquitous tumor regression. However, neither the therapeutic mechanism nor the applicability...

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Bibliographic Details
Main Authors: Sodir, Nicole M., Swigart, Lamorna Brown, Karnezis, Anthony N., Hanahan, Douglas, Evan, Gerard I., Soucek, Laura
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2011
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084025/
https://ncbi.nlm.nih.gov/pubmed/21478273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2038411
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