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Selective activation of p53-mediated tumour suppression in high-grade tumours
Non-small cell lung carcinoma (NSCLC) is the leading cause of cancer-related death worldwide, with an overall 5-year survival rate of only 10–15% 1. Deregulation of the Ras pathway is a frequent hallmark of NSCLC, often through mutations that directly activate Kras 2. p53 is also frequently inactiva...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3011233/ https://ncbi.nlm.nih.gov/pubmed/21107427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09526 |
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