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Validation of MdmX as a therapeutic target for reactivating p53 in tumors
MdmX, also known as Mdm4, is a critical negative regulator of p53, and its overexpression serves to block p53 tumor suppressor function in many cancers. Consequently, inhibiting MdmX has emerged as an attractive approach to restoring p53 function in those cancers that retain functional p53. However,...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3165938/ https://ncbi.nlm.nih.gov/pubmed/21852537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.16722111 |
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