Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy

Based on clinical presentation, glioblastoma (GBM) is stratified into primary and secondary types. The protein 53 (p53) pathway is functionally incapacitated in most GBMs by distinctive type-specific mechanisms. To model human gliomagenesis, we used a GFAP-HRas(V12) mouse model crossed into the p53E...

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Bibliografiske detaljer
Main Authors: Shchors, Ksenya, Persson, Anders I., Rostker, Fanya, Tihan, Tarik, Lyubynska, Natalya, Li, Nan, Swigart, Lamorna Brown, Berger, Mitchel S., Hanahan, Douglas, Weiss, William A., Evan, Gerard I.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631679/
https://ncbi.nlm.nih.gov/pubmed/23542378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219142110
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