Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy

Based on clinical presentation, glioblastoma (GBM) is stratified into primary and secondary types. The protein 53 (p53) pathway is functionally incapacitated in most GBMs by distinctive type-specific mechanisms. To model human gliomagenesis, we used a GFAP-HRas(V12) mouse model crossed into the p53E...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Shchors, Ksenya, Persson, Anders I., Rostker, Fanya, Tihan, Tarik, Lyubynska, Natalya, Li, Nan, Swigart, Lamorna Brown, Berger, Mitchel S., Hanahan, Douglas, Weiss, William A., Evan, Gerard I.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2013
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631679/
https://ncbi.nlm.nih.gov/pubmed/23542378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219142110
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