Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy

Based on clinical presentation, glioblastoma (GBM) is stratified into primary and secondary types. The protein 53 (p53) pathway is functionally incapacitated in most GBMs by distinctive type-specific mechanisms. To model human gliomagenesis, we used a GFAP-HRas(V12) mouse model crossed into the p53E...

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Detalhes bibliográficos
Main Authors: Shchors, Ksenya, Persson, Anders I., Rostker, Fanya, Tihan, Tarik, Lyubynska, Natalya, Li, Nan, Swigart, Lamorna Brown, Berger, Mitchel S., Hanahan, Douglas, Weiss, William A., Evan, Gerard I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631679/
https://ncbi.nlm.nih.gov/pubmed/23542378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219142110
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