Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

Voltage-gated Kv1.3 and Ca(2+)-dependent KCa3.1 are the most prevalent K(+) channels expressed by human and rat T cells. Despite the preferential upregulation of Kv1.3 over KCa3.1 on autoantigen-experienced effector memory T cells, whether Kv1.3 is required for their induction and function is unclea...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Chiang, Eugene Y., Li, Tianbo, Jeet, Surinder, Peng, Ivan, Zhang, Juan, Lee, Wyne P., DeVoss, Jason, Caplazi, Patrick, Chen, Jun, Warming, Søren, Hackos, David H., Mukund, Susmith, Koth, Christopher M., Grogan, Jane L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5337993/
https://ncbi.nlm.nih.gov/pubmed/28248292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14644
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