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Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

Voltage-gated Kv1.3 and Ca(2+)-dependent KCa3.1 are the most prevalent K(+) channels expressed by human and rat T cells. Despite the preferential upregulation of Kv1.3 over KCa3.1 on autoantigen-experienced effector memory T cells, whether Kv1.3 is required for their induction and function is unclea...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Chiang, Eugene Y., Li, Tianbo, Jeet, Surinder, Peng, Ivan, Zhang, Juan, Lee, Wyne P., DeVoss, Jason, Caplazi, Patrick, Chen, Jun, Warming, Søren, Hackos, David H., Mukund, Susmith, Koth, Christopher M., Grogan, Jane L.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5337993/
https://ncbi.nlm.nih.gov/pubmed/28248292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14644
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