The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice

Ox40 ligand (Ox40L) locus genetic variants are associated with the risk for systemic lupus erythematosus (SLE); however, it is unclear how Ox40L contributes to SLE pathogenesis. In this study, we evaluated the contribution of Ox40L and its cognate receptor, Ox40, using in vivo agonist and antagonist...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Sitrin, Jonathan, Suto, Eric, Wuster, Arthur, Eastham-Anderson, Jeffrey, Kim, Jeong M., Austin, Cary D., Lee, Wyne P., Behrens, Timothy W.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2017
Assuntos:
Autoimmunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544932/
https://ncbi.nlm.nih.gov/pubmed/28696253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700608
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