OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T follicular Helper Response

Increased activity of T follicular helper (Tfh) cells plays a major pathogenic role in systemic lupus erythematosus (SLE). However, the mechanisms that cause aberrant Tfh cell responses in SLE remain elusive. Here we showed the OX40 ligand (OX40L)-OX40 axis contributes to the aberrant Tfh response i...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Jacquemin, Clément, Schmitt, Nathalie, Contin-Bordes, Cécile, Liu, Yang, Narayanan, Priya, Seneschal, Julien, Maurouard, Typhanie, Dougall, David, Davizon, Emily Spence, Dumortier, Hélène, Douchet, Isabelle, Raffray, Loïc, Richez, Christophe, Lazaro, Estibaliz, Duffau, Pierre, Truchetet, Marie-Elise, Khoryati, Liliane, Mercié, Patrick, Couzi, Lionel, Merville, Pierre, Schaeverbeke, Thierry, Viallard, Jean-François, Pellegrin, Jean-Luc, Moreau, Jean-François, Muller, Sylviane, Zurawski, Sandy, Coffman, Robert L., Pascual, Virginia, Ueno, Hideki, Blanco, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570857/
https://ncbi.nlm.nih.gov/pubmed/26070486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.05.012
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