OX40L/OX40 axis impairs follicular and natural Treg function in human SLE

Tregs are impaired in human systemic lupus erythematosus (SLE) and contribute to effector T cell activation. However, the mechanisms responsible for the Treg deficiency in SLE remain unclear. We hypothesized that the OX40L/OX40 axis is implicated in Treg and regulatory follicular helper T (Tfr) cell...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Jacquemin, Clément, Augusto, Jean-François, Scherlinger, Marc, Gensous, Noémie, Forcade, Edouard, Douchet, Isabelle, Levionnois, Emeline, Richez, Christophe, Lazaro, Estibaliz, Duffau, Pierre, Truchetet, Marie-Elise, Seneschal, Julien, Couzi, Lionel, Pellegrin, Jean-Luc, Viallard, Jean-François, Schaeverbeke, Thierry, Pascual, Virginia, Contin-Bordes, Cécile, Blanco, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338386/
https://ncbi.nlm.nih.gov/pubmed/30568041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122167
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