The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice

Ox40 ligand (Ox40L) locus genetic variants are associated with the risk for systemic lupus erythematosus (SLE); however, it is unclear how Ox40L contributes to SLE pathogenesis. In this study, we evaluated the contribution of Ox40L and its cognate receptor, Ox40, using in vivo agonist and antagonist...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Immunol
Autori principali: Sitrin, Jonathan, Suto, Eric, Wuster, Arthur, Eastham-Anderson, Jeffrey, Kim, Jeong M., Austin, Cary D., Lee, Wyne P., Behrens, Timothy W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: AAI 2017
Soggetti:
Autoimmunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544932/
https://ncbi.nlm.nih.gov/pubmed/28696253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700608
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi