Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation

Intracellular LPS sensing by caspase-4/5/11 triggers proteolytic activation of pore-forming gasdermin D (GSDMD), leading to pyroptotic cell death in Gram-negative bacteria-infected cells. Involvement of caspase-4/5/11 and GSDMD in inflammatory responses, such as lethal sepsis, makes them highly desi...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Lee, Bettina L., Stowe, Irma B., Gupta, Aaron, Kornfeld, Opher S., Roose-Girma, Merone, Anderson, Keith, Warming, Søren, Zhang, Juan, Lee, Wyne P., Kayagaki, Nobuhiko
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6122968/
https://ncbi.nlm.nih.gov/pubmed/30135078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180589
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