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ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages
The NLRC4 inflammasome recognizes bacterial flagellin and components of the type III secretion apparatus. NLRC4 stimulation leads to caspase-1 activation followed by a rapid lytic cell death known as pyroptosis. NLRC4 is linked to pathogen-free auto-inflammatory diseases, suggesting a role for NLRC4...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5830643/ https://ncbi.nlm.nih.gov/pubmed/29491424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21998-3 |
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