ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages

The NLRC4 inflammasome recognizes bacterial flagellin and components of the type III secretion apparatus. NLRC4 stimulation leads to caspase-1 activation followed by a rapid lytic cell death known as pyroptosis. NLRC4 is linked to pathogen-free auto-inflammatory diseases, suggesting a role for NLRC4...

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Pubblicato in:Sci Rep
Autori principali: Lee, Bettina L., Mirrashidi, Kathleen M., Stowe, Irma B., Kummerfeld, Sarah K., Watanabe, Colin, Haley, Benjamin, Cuellar, Trinna L., Reichelt, Michael, Kayagaki, Nobuhiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830643/
https://ncbi.nlm.nih.gov/pubmed/29491424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21998-3
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