Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates

1. Cell-surface expression of CD40 in B-cell malignancies and multiple solid tumors has raised interest in its potential use as a target for antibody-based cancer therapy. SGN-40, a humanized monoclonal anti-CD40 antibody, mediates antibody-dependent cytotoxicity and inhibits B-cell tumor growth in...

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Main Authors: Kelley, Sean K, Gelzleichter, Thomas, Xie, Dong, Lee, Wyne P, Darbonne, Walter C, Qureshi, Ferhan, Kissler, Kim, Oflazoglu, Ezogelin, Grewal, Iqbal S
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1752010/
https://ncbi.nlm.nih.gov/pubmed/16847437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706828
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