Macrophages and Fc-receptor interactions contribute to the antitumour activities of the anti-CD40 antibody SGN-40

SGN-40 is a therapeutic antibody targeting CD40, which induces potent anti-lymphoma activities via direct apoptotic signalling cells and by cell-mediated cytotoxicity. Here we show antibody-dependent cellular phagocytosis (ADCP) by macrophages to contribute significantly to the therapeutic activitie...

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Main Authors: Oflazoglu, E, Stone, I J, Brown, L, Gordon, K A, van Rooijen, N, Jonas, M, Law, C-L, Grewal, I S, Gerber, H-P
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2009
Fag:
Translational Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634668/
https://ncbi.nlm.nih.gov/pubmed/19066610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604812
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