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Thrombin Inhibition by Serpins Disrupts Exosite II

Thrombin uses three principal sites, the active site, exosite I, and exosite II, for recognition of its many cofactors and substrates. It is synthesized in the zymogen form, prothrombin, and its activation at the end of the blood coagulation cascade results in the formation of the active site and ex...

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Autores principales: Li, Wei, Johnson, Daniel J. D., Adams, Ty E., Pozzi, Nicola, De Filippis, Vincenzo, Huntington, James A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992294/
https://ncbi.nlm.nih.gov/pubmed/20889971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.144964
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