Thrombin Inhibition by Serpins Disrupts Exosite II

Thrombin uses three principal sites, the active site, exosite I, and exosite II, for recognition of its many cofactors and substrates. It is synthesized in the zymogen form, prothrombin, and its activation at the end of the blood coagulation cascade results in the formation of the active site and ex...

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Библиографические подробности
Главные авторы: Li, Wei, Johnson, Daniel J. D., Adams, Ty E., Pozzi, Nicola, De Filippis, Vincenzo, Huntington, James A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
Предметы:
Protein Structure and Folding
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992294/
https://ncbi.nlm.nih.gov/pubmed/20889971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.144964
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