Ligand Binding to Anion-binding Exosites Regulates Conformational Properties of Thrombin

Thrombin participates in coagulation, anticoagulation, and initiation of platelet activation. To fulfill its diverse roles and maintain hemostasis, this serine protease is regulated via the extended active site region and anion-binding exosites (ABEs) I and II. For the current project, amide proton...

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Bibliographic Details
Main Authors: Malovichko, Marina V., Sabo, T. Michael, Maurer, Muriel C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605685/
https://ncbi.nlm.nih.gov/pubmed/23378535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.410829
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