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Ligand Binding to Anion-binding Exosites Regulates Conformational Properties of Thrombin
Thrombin participates in coagulation, anticoagulation, and initiation of platelet activation. To fulfill its diverse roles and maintain hemostasis, this serine protease is regulated via the extended active site region and anion-binding exosites (ABEs) I and II. For the current project, amide proton...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3605685/ https://ncbi.nlm.nih.gov/pubmed/23378535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.410829 |
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