Thrombin Exosite Maturation and Ligand Binding at ABE II Help Stabilize PAR Binding Competent Conformation at ABE I

Thrombin, derived from zymogen prothrombin (ProT), is a serine protease involved in procoagulation, anticoagulation, and platelet activation. Thrombin’s actions are regulated through Anion Binding Exosites I and II (ABE I and ABE II) that undergo maturation during activation. Mature ABEs can utilize...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Billur, Ramya, Sabo, T. Michael, Maurer, Muriel C.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6716794/
https://ncbi.nlm.nih.gov/pubmed/30672691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00943
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