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Thrombin Hydrolysis of Human Osteopontin Is Dependent on Thrombin Anion-binding Exosites
The cytokine osteopontin (OPN) can be hydrolyzed by thrombin exposing a cryptic α(4)β(1)/α(9)β(1) integrin-binding motif (SVVYGLR), thereby acting as a potent cytokine for cells bearing these activated integrins. We show that purified milk OPN is a substrate for thrombin with a k(cat)/K(m) value of...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2440630/ https://ncbi.nlm.nih.gov/pubmed/18413297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708629200 |
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