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Deciphering Conformational Changes Associated with the Maturation of Thrombin Anion Binding Exosite I
Thrombin participates in procoagulation, anticoagulation, and platelet activation. This enzyme contains anion binding exosites, ABE I and ABE II, which attract regulatory biomolecules. As prothrombin is activated to thrombin, pro-ABE I is converted into mature ABE I. Unexpectedly, certain ligands ca...
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| Опубликовано в: : | Biochemistry |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6076386/ https://ncbi.nlm.nih.gov/pubmed/29111672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00970 |
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