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Long Range Communication between Exosites 1 and 2 Modulates Thrombin Function
Although exosites 1 and 2 regulate thrombin activity by binding substrates and cofactors and by allosterically modulating the active site, it is unclear whether there is direct allosteric linkage between the two exosites. To begin to address this, we first titrated a thrombin variant fluorescently l...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2757964/ https://ncbi.nlm.nih.gov/pubmed/19589779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.000042 |
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