Long Range Communication between Exosites 1 and 2 Modulates Thrombin Function

Although exosites 1 and 2 regulate thrombin activity by binding substrates and cofactors and by allosterically modulating the active site, it is unclear whether there is direct allosteric linkage between the two exosites. To begin to address this, we first titrated a thrombin variant fluorescently l...

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Main Authors: Petrera, Nicolas S., Stafford, Alan R., Leslie, Beverly A., Kretz, Colin A., Fredenburgh, James C., Weitz, Jeffrey I.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2009
Ábhair:
Protein Structure and Folding
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757964/
https://ncbi.nlm.nih.gov/pubmed/19589779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.000042
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