Long Range Communication between Exosites 1 and 2 Modulates Thrombin Function

Although exosites 1 and 2 regulate thrombin activity by binding substrates and cofactors and by allosterically modulating the active site, it is unclear whether there is direct allosteric linkage between the two exosites. To begin to address this, we first titrated a thrombin variant fluorescently l...

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Detalhes bibliográficos
Main Authors: Petrera, Nicolas S., Stafford, Alan R., Leslie, Beverly A., Kretz, Colin A., Fredenburgh, James C., Weitz, Jeffrey I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757964/
https://ncbi.nlm.nih.gov/pubmed/19589779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.000042
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