Factors XI and XII as Targets for New Anticoagulants

Por Weitz, Jeffrey I., Fredenburgh, James C.
Publicado no Front Med (Lausanne) (2017)

Recent advances in the treatment of venous thromboembolism in the era of the direct oral anticoagulants

Por Weitz, Jeffrey I., Jaffer, Iqbal H., Fredenburgh, James C.
Publicado no F1000Res (2017)

HD1, a thrombin-directed aptamer, binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinase.

Por Kretz, Colin A., Stafford, Alan R., Fredenburgh, James C., Weitz, Jeffrey I.
Publicado no J Biol Chem (2015)

A High Affinity Interaction of Plasminogen with Fibrin Is Not Essential for Efficient Activation by Tissue-type Plasminogen Activator

Por Kim, Paul Y., Tieu, Long D., Stafford, Alan R., Fredenburgh, James C., Weitz, Jeffrey I.
Publicado em 2012

Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function

Por Yeh, Calvin H., Stafford, Alan R., Leslie, Beverly A., Fredenburgh, James C., Weitz, Jeffrey I.
Publicado no PLoS One (2016)

Long Range Communication between Exosites 1 and 2 Modulates Thrombin Function

Por Petrera, Nicolas S., Stafford, Alan R., Leslie, Beverly A., Kretz, Colin A., Fredenburgh, James C., Weitz, Jeffrey I.
Publicado em 2009

Histidine-rich Glycoprotein Binds Fibrin(ogen) with High Affinity and Competes with Thrombin for Binding to the γ′-Chain

Por Vu, Trang T., Stafford, Alan R., Leslie, Beverly A., Kim, Paul Y., Fredenburgh, James C., Weitz, Jeffrey I.
Publicado em 2011

Batroxobin Binds Fibrin with Higher Affinity and Promotes Clot Expansion to a Greater Extent than Thrombin

Por Vu, Trang T., Stafford, Alan R., Leslie, Beverly A., Kim, Paul Y., Fredenburgh, James C., Weitz, Jeffrey I.
Publicado em 2013

Zn(2+) Mediates High Affinity Binding of Heparin to the αC Domain of Fibrinogen

Por Fredenburgh, James C., Leslie, Beverly A., Stafford, Alan R., Lim, Teresa, Chan, Howard H., Weitz, Jeffrey I.
Publicado em 2013

Reduced Plasminogen Binding and Delayed Activation Render γ′-Fibrin More Resistant to Lysis than γ(A)-Fibrin

Por Kim, Paul Y., Vu, Trang T., Leslie, Beverly A., Stafford, Alan R., Fredenburgh, James C., Weitz, Jeffrey I.
Publicado em 2014

Long range communication between exosites 1 and 2 modulates thrombin function.

Por Petrera, Nicolas S., Stafford, Alan R., Leslie, Beverly A., Kretz, Colin A., Fredenburgh, James C., Weitz, Jeffrey I.
Publicado no J Biol Chem (2015)

Dabigatran is Less Effective Than Warfarin at Attenuating Mechanical Heart Valve-Induced Thrombin Generation

Por Jaffer, Iqbal H, Stafford, Alan R, Fredenburgh, James C, Whitlock, Richard P, Chan, Noel C, Weitz, Jeffrey I
Publicado no J Am Heart Assoc (2015)

Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein

Por Vu, Trang T., Zhou, Ji, Leslie, Beverly A., Stafford, Alan R., Fredenburgh, James C., Ni, Ran, Qiao, Shengjun, Vaezzadeh, Nima, Jahnen-Dechent, Willi, Monia, Brett P., Gross, Peter L., Weitz, Jeffrey I.
Publicado no Blood (2015)