Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite

By virtue of its amplifying property, the alternative complement pathway has been implicated in a number of inflammatory diseases and constitutes an attractive therapeutic target. An anti-factor D Fab fragment (AFD) was generated to inhibit the alternative complement pathway in advanced dry age-rela...

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Détails bibliographiques
Auteurs principaux: Katschke, Kenneth J., Wu, Ping, Ganesan, Rajkumar, Kelley, Robert F., Mathieu, Mary A., Hass, Philip E., Murray, Jeremy, Kirchhofer, Daniel, Wiesmann, Christian, van Lookeren Campagne, Menno
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Protein Structure and Folding
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339934/
https://ncbi.nlm.nih.gov/pubmed/22362762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.345082
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