Compartmental Tissue Distribution of Antibody Therapeutics: Experimental Approaches and Interpretations

Por Boswell, C. Andrew, Bumbaca, Daniela, Fielder, Paul J., Khawli, Leslie A.
Publicado em 2012

Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics

Por Bumbaca, Daniela, Boswell, C. Andrew, Fielder, Paul J., Khawli, Leslie A.
Publicado em 2012

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: What have we learned?

Por Deng, Rong, Iyer, Suhasini, Theil, Frank-Peter, Mortensen, Deborah L, Fielder, Paul J, Prabhu, Saileta
Publicado em 2011

Effects of Anti-VEGF on Predicted Antibody Biodistribution: Roles of Vascular Volume, Interstitial Volume, and Blood Flow

Por Boswell, C. Andrew, Ferl, Gregory Z., Mundo, Eduardo E., Bumbaca, Daniela, Schweiger, Michelle G., Theil, Frank-Peter, Fielder, Paul J., Khawli, Leslie A.
Publicado em 2011

Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice

Por Deng, Rong, Meng, Y Gloria, Hoyte, Kwame, Lutman, Jeff, Lu, Yanmei, Iyer, Suhasini, DeForge, Laura E, Theil, Frank-Peter, Fielder, Paul J, Prabhu, Saileta
Publicado em 2012

Use of Quantitative Pharmacology in the Development of HAE1, a High-Affinity Anti-IgE Monoclonal Antibody

Por Putnam, Wendy S., Li, Jing, Haggstrom, Jonas, Ng, Chee, Kadkhodayan-Fischer, Saloumeh, Cheu, Melissa, Deniz, Yamo, Lowman, Henry, Fielder, Paul, Visich, Jennifer, Joshi, Amita, Jumbe, Nelson “Shasha”
Publicado em 2008

Effect of antigen binding affinity and effector function on the pharmacokinetics and pharmacodynamics of anti-IgE monoclonal antibodies

Por Mortensen, Deborah L., Prabhu, Saileta, Stefanich, Eric G., Kadkhodayan-Fischer, Saloumeh, Gelzleichter, Thomas R., Baker, Dana, Jiang, Jenny, Wallace, Kristin, Iyer, Suhasini, Fielder, Paul J., Putnam, Wendy S.
Publicado em 2012

A strategy for risk mitigation of antibodies with fast clearance

Por Hötzel, Isidro, Theil, Frank-Peter, Bernstein, Lisa J., Prabhu, Saileta, Deng, Rong, Quintana, Leah, Lutman, Jeff, Sibia, Renuka, Chan, Pamela, Bumbaca, Daniela, Fielder, Paul, Carter, Paul J., Kelley, Robert F.
Publicado em 2012

Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice

Por Bumbaca, Daniela, Xiang, Hong, Boswell, C Andrew, Port, Ruediger E, Stainton, Shannon L, Mundo, Eduardo E, Ulufatu, Sheila, Bagri, Anil, Theil, Frank-Peter, Fielder, Paul J, Khawli, Leslie A, Shen, Ben-Quan
Publicado em 2012

Quantitative cumulative biodistribution of antibodies in mice: Effect of modulating binding affinity to the neonatal Fc receptor

Por Yip, Victor, Palma, Enzo, Tesar, Devin B, Mundo, Eduardo E, Bumbaca, Daniela, Torres, Elizabeth K, Reyes, Noe A, Shen, Ben Q, Fielder, Paul J, Prabhu, Saileta, Khawli, Leslie A, Boswell, C Andrew
Publicado em 2014

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

Por Zheng, Yanan, Tesar, Devin B, Benincosa, Lisa, Birnböck, Herbert, Boswell, C Andrew, Bumbaca, Daniela, Cowan, Kyra J, Danilenko, Dimitry M, Daugherty, Ann L, Fielder, Paul J, Grimm, Hans Peter, Joshi, Amita, Justies, Nicole, Kolaitis, Gerry, Lewin-Koh, Nicholas, Li, Jing, McVay, Sami, O'Mahony, Jennifer, Otteneder, Michael, Pantze, Michael, Putnam, Wendy S, Qiu, Zhihua J, Ruppel, Jane, Singer, Thomas, Stauch, Oliver, Theil, Frank-Peter, Visich, Jennifer, Yang, Jihong, Ying, Yong, Khawli, Leslie A, Richter, Wolfgang F
Publicado em 2012