Use of Quantitative Pharmacology in the Development of HAE1, a High-Affinity Anti-IgE Monoclonal Antibody

HAE1, a high-affinity anti-IgE monoclonal antibody, is discussed here as a case study in the use of quantitative pharmacology in the development of a second-generation molecule. In vitro, preclinical, and clinical data from the first-generation molecule, omalizumab, were heavily leveraged in the HAE...

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Detalhes bibliográficos
Main Authors: Putnam, Wendy S., Li, Jing, Haggstrom, Jonas, Ng, Chee, Kadkhodayan-Fischer, Saloumeh, Cheu, Melissa, Deniz, Yamo, Lowman, Henry, Fielder, Paul, Visich, Jennifer, Joshi, Amita, Jumbe, Nelson “Shasha”
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2008
Assuntos:
Review Article/Theme: Quantitative Pharmacology, a Roadmap for Rational, Model-Based Drug Dev/Guest Editor: B. Meibohm
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751395/
https://ncbi.nlm.nih.gov/pubmed/18686041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-008-9045-4
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