Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

Subcutaneous (SC) delivery is a common route of administration for therapeutic monoclonal antibodies (mAbs) with pharmacokinetic (PK)/pharmacodynamic (PD) properties requiring long-term or frequent drug administration. An ideal in vivo preclinical model for predicting human PK following SC administr...

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Detalhes bibliográficos
Main Authors: Zheng, Yanan, Tesar, Devin B, Benincosa, Lisa, Birnböck, Herbert, Boswell, C Andrew, Bumbaca, Daniela, Cowan, Kyra J, Danilenko, Dimitry M, Daugherty, Ann L, Fielder, Paul J, Grimm, Hans Peter, Joshi, Amita, Justies, Nicole, Kolaitis, Gerry, Lewin-Koh, Nicholas, Li, Jing, McVay, Sami, O'Mahony, Jennifer, Otteneder, Michael, Pantze, Michael, Putnam, Wendy S, Qiu, Zhihua J, Ruppel, Jane, Singer, Thomas, Stauch, Oliver, Theil, Frank-Peter, Visich, Jennifer, Yang, Jihong, Ying, Yong, Khawli, Leslie A, Richter, Wolfgang F
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361660/
https://ncbi.nlm.nih.gov/pubmed/22453096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.4.2.19387
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