Antibody targeted CpG for the immunotherapy of solid tumors

מאת Epstein, Alan L, Jang, Julie, Hu, Peisheng, Khawli, Leslie A
הוצא לאור ב J Immunother Cancer (2015)

Principles of N-Linked Glycosylation Variations of IgG-Based Therapeutics: Pharmacokinetic and Functional Considerations

מאת Boune, Souad, Hu, Peisheng, Epstein, Alan L., Khawli, Leslie A.
הוצא לאור ב Antibodies (Basel) (2020)

Compartmental Tissue Distribution of Antibody Therapeutics: Experimental Approaches and Interpretations

מאת Boswell, C. Andrew, Bumbaca, Daniela, Fielder, Paul J., Khawli, Leslie A.
יצא לאור 2012

Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics

מאת Bumbaca, Daniela, Boswell, C. Andrew, Fielder, Paul J., Khawli, Leslie A.
יצא לאור 2012

Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development

מאת Tibbitts, Jay, Canter, David, Graff, Ryan, Smith, Alison, Khawli, Leslie A.
הוצא לאור ב MAbs (2015)

Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges

מאת Vugmeyster, Yulia, Xu, Xin, Theil, Frank-Peter, Khawli, Leslie A, Leach, Michael W
יצא לאור 2012

Recent Advances in Assessing Immunogenicity of Therapeutic Proteins: Impact on Biotherapeutic Development

מאת Lu, Yanmei, Khawli, Leslie A., Purushothama, Shobha, Theil, Frank-Peter, Partridge, Michael A.
הוצא לאור ב J Immunol Res (2016)

Brain Disposition of Antibody-Based Therapeutics: Dogma, Approaches and Perspectives

מאת Kouhi, Aida, Pachipulusu, Vyshnavi, Kapenstein, Talya, Hu, Peisheng, Epstein, Alan L., Khawli, Leslie A.
הוצא לאור ב Int J Mol Sci (2021)

Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins

מאת Smith, Alison, Manoli, Hugh, Jaw, Stacey, Frutoz, Kimberley, Epstein, Alan L., Khawli, Leslie A., Theil, Frank-Peter
הוצא לאור ב J Immunol Res (2016)

Lym-1 Chimeric Antigen Receptor T Cells Exhibit Potent Anti-Tumor Effects against B-Cell Lymphoma

מאת Zheng, Long, Hu, Peisheng, Wolfe, Brandon, Gonsalves, Caryn, Ren, Luqing, Khawli, Leslie A., Kaslow, Harvey R., Epstein, Alan L.
הוצא לאור ב Int J Mol Sci (2017)

Cytoreductive Chemotherapy Improves the Biodistribution of Antibodies Directed Against Tumor Necrosis in Murine Solid Tumor Models

מאת Jang, Julie K., Khawli, Leslie A., Park, Ryan, Wu, Brian W., Li, Zibo, Canter, David, Conti, Peter S., Epstein, Alan L.
יצא לאור 2013

Effects of Anti-VEGF on Predicted Antibody Biodistribution: Roles of Vascular Volume, Interstitial Volume, and Blood Flow

מאת Boswell, C. Andrew, Ferl, Gregory Z., Mundo, Eduardo E., Bumbaca, Daniela, Schweiger, Michelle G., Theil, Frank-Peter, Fielder, Paul J., Khawli, Leslie A.
יצא לאור 2011

Systemic delivery of chTNT-3/CpG immunoconjugates for immunotherapy in murine solid tumor models

מאת Jang, Julie K., Khawli, Leslie A., Canter, David C., Hu, Peisheng, Zhu, Tian H., Wu, Brian W., Angell, Trevor E., Li, Zhongjun, Epstein, Alan L.
הוצא לאור ב Cancer Immunol Immunother (2016)

Spatio-temporal biodistribution of (89)Zr-oxine labeled huLym-1-A-BB3z-CAR T-cells by PET imaging in a preclinical tumor model

מאת Sta Maria, Naomi S., Khawli, Leslie A., Pachipulusu, Vyshnavi, Lin, Sharon W., Zheng, Long, Cohrs, Daniel, Liu, Xiaodan, Hu, Peisheng, Epstein, Alan L., Jacobs, Russell E.
הוצא לאור ב Sci Rep (2021)

Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice

מאת Bumbaca, Daniela, Xiang, Hong, Boswell, C Andrew, Port, Ruediger E, Stainton, Shannon L, Mundo, Eduardo E, Ulufatu, Sheila, Bagri, Anil, Theil, Frank-Peter, Fielder, Paul J, Khawli, Leslie A, Shen, Ben-Quan
יצא לאור 2012

Quantitative cumulative biodistribution of antibodies in mice: Effect of modulating binding affinity to the neonatal Fc receptor

מאת Yip, Victor, Palma, Enzo, Tesar, Devin B, Mundo, Eduardo E, Bumbaca, Daniela, Torres, Elizabeth K, Reyes, Noe A, Shen, Ben Q, Fielder, Paul J, Prabhu, Saileta, Khawli, Leslie A, Boswell, C Andrew
יצא לאור 2014

An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2

מאת Boswell, C Andrew, Mundo, Eduardo E, Firestein, Ron, Zhang, Crystal, Mao, Weiguang, Gill, Herman, Young, Cynthia, Ljumanovic, Nina, Stainton, Shannon, Ulufatu, Sheila, Fourie, Aimee, Kozak, Katherine R, Fuji, Reina, Polakis, Paul, Khawli, Leslie A, Lin, Kedan
יצא לאור 2013

Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer

מאת Boswell, C. Andrew, Yadav, Daniela Bumbaca, Mundo, Eduardo E., Yu, Shang-Fan, Lacap, Jennifer Arca, Fourie-O’Donohue, Aimee, Kozak, Katherine R., Ferl, Gregory Z., Zhang, Crystal, Ho, Jason, Ulufatu, Sheila, Khawli, Leslie A., Lin, Kedan
הוצא לאור ב Oncotarget (2019)

Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics

מאת Bumbaca Yadav, Daniela, Sharma, Vikas K., Boswell, Charles Andrew, Hotzel, Isidro, Tesar, Devin, Shang, Yonglei, Ying, Yong, Fischer, Saloumeh K., Grogan, Jane L., Chiang, Eugene Y., Urban, Konnie, Ulufatu, Sheila, Khawli, Leslie A., Prabhu, Saileta, Joseph, Sean, Kelley, Robert F.
הוצא לאור ב J Biol Chem (2015)

Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats

מאת Khawli, Leslie A, Goswami, Sirj, Hutchinson, Ryan, Kwong, Zephania W, Yang, Jihong, Wang, Xiangdan, Yao, Zhenling, Sreedhara, Alavattam, Cano, Tony, Tesar, Devin, Nijem, Ihsan, Allison, David E, Wong, Pin Yee, Kao, Yung-Hsiang, Quan, Cynthia, Joshi, Amita, Harris, Reed J, Motchnik, Paul
יצא לאור 2010