Antibody targeted CpG for the immunotherapy of solid tumors

Por Epstein, Alan L, Jang, Julie, Hu, Peisheng, Khawli, Leslie A
Publicado no J Immunother Cancer (2015)

Compartmental Tissue Distribution of Antibody Therapeutics: Experimental Approaches and Interpretations

Por Boswell, C. Andrew, Bumbaca, Daniela, Fielder, Paul J., Khawli, Leslie A.
Publicado em 2012

Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics

Por Bumbaca, Daniela, Boswell, C. Andrew, Fielder, Paul J., Khawli, Leslie A.
Publicado em 2012

Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development

Por Tibbitts, Jay, Canter, David, Graff, Ryan, Smith, Alison, Khawli, Leslie A.
Publicado no MAbs (2015)

Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges

Por Vugmeyster, Yulia, Xu, Xin, Theil, Frank-Peter, Khawli, Leslie A, Leach, Michael W
Publicado em 2012

Recent Advances in Assessing Immunogenicity of Therapeutic Proteins: Impact on Biotherapeutic Development

Por Lu, Yanmei, Khawli, Leslie A., Purushothama, Shobha, Theil, Frank-Peter, Partridge, Michael A.
Publicado no J Immunol Res (2016)

Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins

Por Smith, Alison, Manoli, Hugh, Jaw, Stacey, Frutoz, Kimberley, Epstein, Alan L., Khawli, Leslie A., Theil, Frank-Peter
Publicado no J Immunol Res (2016)

Cytoreductive Chemotherapy Improves the Biodistribution of Antibodies Directed Against Tumor Necrosis in Murine Solid Tumor Models

Por Jang, Julie K., Khawli, Leslie A., Park, Ryan, Wu, Brian W., Li, Zibo, Canter, David, Conti, Peter S., Epstein, Alan L.
Publicado em 2013

Effects of Anti-VEGF on Predicted Antibody Biodistribution: Roles of Vascular Volume, Interstitial Volume, and Blood Flow

Por Boswell, C. Andrew, Ferl, Gregory Z., Mundo, Eduardo E., Bumbaca, Daniela, Schweiger, Michelle G., Theil, Frank-Peter, Fielder, Paul J., Khawli, Leslie A.
Publicado em 2011

Systemic delivery of chTNT-3/CpG immunoconjugates for immunotherapy in murine solid tumor models

Por Jang, Julie K., Khawli, Leslie A., Canter, David C., Hu, Peisheng, Zhu, Tian H., Wu, Brian W., Angell, Trevor E., Li, Zhongjun, Epstein, Alan L.
Publicado no Cancer Immunol Immunother (2016)

Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice

Por Bumbaca, Daniela, Xiang, Hong, Boswell, C Andrew, Port, Ruediger E, Stainton, Shannon L, Mundo, Eduardo E, Ulufatu, Sheila, Bagri, Anil, Theil, Frank-Peter, Fielder, Paul J, Khawli, Leslie A, Shen, Ben-Quan
Publicado em 2012

Quantitative cumulative biodistribution of antibodies in mice: Effect of modulating binding affinity to the neonatal Fc receptor

Por Yip, Victor, Palma, Enzo, Tesar, Devin B, Mundo, Eduardo E, Bumbaca, Daniela, Torres, Elizabeth K, Reyes, Noe A, Shen, Ben Q, Fielder, Paul J, Prabhu, Saileta, Khawli, Leslie A, Boswell, C Andrew
Publicado em 2014

An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2

Por Boswell, C Andrew, Mundo, Eduardo E, Firestein, Ron, Zhang, Crystal, Mao, Weiguang, Gill, Herman, Young, Cynthia, Ljumanovic, Nina, Stainton, Shannon, Ulufatu, Sheila, Fourie, Aimee, Kozak, Katherine R, Fuji, Reina, Polakis, Paul, Khawli, Leslie A, Lin, Kedan
Publicado em 2013

Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics

Por Bumbaca Yadav, Daniela, Sharma, Vikas K., Boswell, Charles Andrew, Hotzel, Isidro, Tesar, Devin, Shang, Yonglei, Ying, Yong, Fischer, Saloumeh K., Grogan, Jane L., Chiang, Eugene Y., Urban, Konnie, Ulufatu, Sheila, Khawli, Leslie A., Prabhu, Saileta, Joseph, Sean, Kelley, Robert F.
Publicado no J Biol Chem (2015)

Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats

Por Khawli, Leslie A, Goswami, Sirj, Hutchinson, Ryan, Kwong, Zephania W, Yang, Jihong, Wang, Xiangdan, Yao, Zhenling, Sreedhara, Alavattam, Cano, Tony, Tesar, Devin, Nijem, Ihsan, Allison, David E, Wong, Pin Yee, Kao, Yung-Hsiang, Quan, Cynthia, Joshi, Amita, Harris, Reed J, Motchnik, Paul
Publicado em 2010

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

Por Zheng, Yanan, Tesar, Devin B, Benincosa, Lisa, Birnböck, Herbert, Boswell, C Andrew, Bumbaca, Daniela, Cowan, Kyra J, Danilenko, Dimitry M, Daugherty, Ann L, Fielder, Paul J, Grimm, Hans Peter, Joshi, Amita, Justies, Nicole, Kolaitis, Gerry, Lewin-Koh, Nicholas, Li, Jing, McVay, Sami, O'Mahony, Jennifer, Otteneder, Michael, Pantze, Michael, Putnam, Wendy S, Qiu, Zhihua J, Ruppel, Jane, Singer, Thomas, Stauch, Oliver, Theil, Frank-Peter, Visich, Jennifer, Yang, Jihong, Ying, Yong, Khawli, Leslie A, Richter, Wolfgang F
Publicado em 2012