Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice

BACKGROUND AND PURPOSE: Neuropilin-1 (NRP1) is a VEGF receptor that is widely expressed in normal tissues and is involved in tumour angiogenesis. MNRP1685A is a rodent and primate cross-binding human monoclonal antibody against NRP1 that exhibits inhibition of tumour growth in NPR1-expressing precli...

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Bibliographische Detailangaben
Hauptverfasser: Bumbaca, Daniela, Xiang, Hong, Boswell, C Andrew, Port, Ruediger E, Stainton, Shannon L, Mundo, Eduardo E, Ulufatu, Sheila, Bagri, Anil, Theil, Frank-Peter, Fielder, Paul J, Khawli, Leslie A, Shen, Ben-Quan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2012
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415661/
https://ncbi.nlm.nih.gov/pubmed/22074316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01777.x
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