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Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: What have we learned?
The pharmacokinetics (PK) of therapeutic antibodies is determined by target and non-target mediated mechanisms. These antibody-specific factors need to be considered during prediction of human PK based upon preclinical information. Principles of allometric scaling established for small molecules usi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3038012/ https://ncbi.nlm.nih.gov/pubmed/20962582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.3.1.13799 |
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