Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice

The neonatal Fc receptor (FcRn) plays an important and well-known role in immunoglobulin G (IgG) catabolism; however, its role in the disposition of IgG after subcutaneous (SC) administration, including bioavailability, is relatively unknown. To examine the potential effect of FcRn on IgG SC bioavai...

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Detalhes bibliográficos
Main Authors: Deng, Rong, Meng, Y Gloria, Hoyte, Kwame, Lutman, Jeff, Lu, Yanmei, Iyer, Suhasini, DeForge, Laura E, Theil, Frank-Peter, Fielder, Paul J, Prabhu, Saileta
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3338944/
https://ncbi.nlm.nih.gov/pubmed/22327433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.4.1.18543
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