Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies

The neonatal Fc receptor (FcRn) is important for the metabolic fate of IgG antibodies in vivo. Analysis of the interaction between FcRn and IgG in vitro might provide insight into the structural and functional integrity of therapeutic IgG that may affect pharmacokinetics (PK) in vivo. We developed a...

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Bibliografske podrobnosti
Main Authors: Schlothauer, Tilman, Rueger, Petra, Stracke, Jan Olaf, Hertenberger, Hubert, Fingas, Felix, Kling, Lothar, Emrich, Thomas, Drabner, Georg, Seeber, Stefan, Auer, Johannes, Koch, Stefan, Papadimitriou, Apollon
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2013
Teme:
Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906311/
https://ncbi.nlm.nih.gov/pubmed/23765230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.24981
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