A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies

Preserving the chemical and structural integrity of therapeutic antibodies during manufacturing and storage is a major challenge during pharmaceutical development. Oxidation of Fc methionines Met252 and Met428 is frequently observed, which leads to reduced affinity to FcRn and faster plasma clearanc...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Stracke, Jan, Emrich, Thomas, Rueger, Petra, Schlothauer, Tilman, Kling, Lothar, Knaupp, Alexander, Hertenberger, Hubert, Wolfert, Andreas, Spick, Christian, Lau, Wilma, Drabner, Georg, Reiff, Ulrike, Koll, Hans, Papadimitriou, Apollon
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2014
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622569/
https://ncbi.nlm.nih.gov/pubmed/25517308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.29601
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