Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics

Here, we investigated the influence of the variable fragment (Fv) of IgG antibodies on the binding to the neonatal Fc receptor (FcRn) as well as on FcRn-dependent pharmacokinetics (PK). FcRn plays a key role in IgG homeostasis, and specific manipulation in the crystallizable fragment (Fc) is known t...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Schoch, Angela, Kettenberger, Hubert, Mundigl, Olaf, Winter, Gerhard, Engert, Julia, Heinrich, Julia, Emrich, Thomas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2015
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434771/
https://ncbi.nlm.nih.gov/pubmed/25918417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408766112
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