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Pharmacokinetic Models for FcRn-Mediated IgG Disposition
The objectives were to review available PK models for saturable FcRn-mediated IgG disposition, and to explore an alternative semimechanistic model. Most available empirical and mechanistic PK models assumed equal IgG concentrations in plasma and endosome in addition to other model-specific assumptio...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Hindawi Publishing Corporation
2012
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3361741/ https://ncbi.nlm.nih.gov/pubmed/22665983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/282989 |
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