Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys

Antibody interactions with Fcγ receptors (FcγRs), like FcγRIIIA, play a critical role in mediating antibody effector functions and thereby contribute significantly to the biologic and therapeutic activity of antibodies. Over the past decade, considerable work has been directed towards production of...

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Bibliografske podrobnosti
Main Authors: Leabman, Maya K, Meng, Y Gloria, Kelley, Robert F, DeForge, Laura E, Cowan, Kyra J, Iyer, Suhasini
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2013
Teme:
Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896603/
https://ncbi.nlm.nih.gov/pubmed/24492343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.26436
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