In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

For mAbs to be viable therapeutics, they must be formulated to have low viscosity, be chemically stable, and have normal in vivo clearance rates. We explored these properties by observing correlations of up to 60 different antibodies of the IgG1 isotype. Unexpectedly, we observe significant correlat...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sharma, Vikas K., Patapoff, Thomas W., Kabakoff, Bruce, Pai, Satyan, Hilario, Eric, Zhang, Boyan, Li, Charlene, Borisov, Oleg, Kelley, Robert F., Chorny, Ilya, Zhou, Joe Z., Dill, Ken A., Swartz, Trevor E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284567/
https://ncbi.nlm.nih.gov/pubmed/25512516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421779112
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