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In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability
For mAbs to be viable therapeutics, they must be formulated to have low viscosity, be chemically stable, and have normal in vivo clearance rates. We explored these properties by observing correlations of up to 60 different antibodies of the IgG1 isotype. Unexpectedly, we observe significant correlat...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4284567/ https://ncbi.nlm.nih.gov/pubmed/25512516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421779112 |
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