In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

For mAbs to be viable therapeutics, they must be formulated to have low viscosity, be chemically stable, and have normal in vivo clearance rates. We explored these properties by observing correlations of up to 60 different antibodies of the IgG1 isotype. Unexpectedly, we observe significant correlat...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Sharma, Vikas K., Patapoff, Thomas W., Kabakoff, Bruce, Pai, Satyan, Hilario, Eric, Zhang, Boyan, Li, Charlene, Borisov, Oleg, Kelley, Robert F., Chorny, Ilya, Zhou, Joe Z., Dill, Ken A., Swartz, Trevor E.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2014
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284567/
https://ncbi.nlm.nih.gov/pubmed/25512516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421779112
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