Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations

The solution dynamics of antibodies are critical to antibody function. We explore the internal solution dynamics of antibody molecules through the combination of time-resolved fluorescence anisotropy experiments on IgG1 with more than two microseconds of all-atom molecular dynamics (MD) simulations...

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Main Authors: Kortkhonjia, Ekaterine, Brandman, Relly, Zhou, Joe Zhongxiang, Voelz, Vincent A., Chorny, Ilya, Kabakoff, Bruce, Patapoff, Thomas W., Dill, Ken A., Swartz, Trevor E.
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893241/
https://ncbi.nlm.nih.gov/pubmed/23396076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.23651
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