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Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations
The solution dynamics of antibodies are critical to antibody function. We explore the internal solution dynamics of antibody molecules through the combination of time-resolved fluorescence anisotropy experiments on IgG1 with more than two microseconds of all-atom molecular dynamics (MD) simulations...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Landes Bioscience
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3893241/ https://ncbi.nlm.nih.gov/pubmed/23396076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.23651 |
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