Probing antibody internal dynamics with fluorescence anisotropy and molecular dynamics simulations

The solution dynamics of antibodies are critical to antibody function. We explore the internal solution dynamics of antibody molecules through the combination of time-resolved fluorescence anisotropy experiments on IgG1 with more than two microseconds of all-atom molecular dynamics (MD) simulations...

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Autores principales: Kortkhonjia, Ekaterine, Brandman, Relly, Zhou, Joe Zhongxiang, Voelz, Vincent A., Chorny, Ilya, Kabakoff, Bruce, Patapoff, Thomas W., Dill, Ken A., Swartz, Trevor E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893241/
https://ncbi.nlm.nih.gov/pubmed/23396076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.23651
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