Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme

Por Elling, Robert A., Fucini, Raymond V., Hanan, Emily J., Barr, Kenneth J., Zhu, Jiang, Paulvannan, Kumar, Yang, Wenjin, Romanowski, Michael J.
Publicado em 2008

Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye

Por Zhong, Min, Gadek, Thomas R., Bui, Minna, Shen, Wang, Burnier, John, Barr, Kenneth J., Hanan, Emily J., Oslob, Johan D., Yu, Chul H., Zhu, Jiang, Arkin, Michelle R., Evanchik, Marc J., Flanagan, W. Mike, Hoch, Ute, Hyde, Jennifer, Prabhu, Saileta, Silverman, Jeffrey A., Wright, Jasmin
Publicado em 2012

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR

Por Bryan, Marian C., Burdick, Daniel J., Chan, Bryan K., Chen, Yuan, Clausen, Saundra, Dotson, Jennafer, Eigenbrot, Charles, Elliott, Richard, Hanan, Emily J., Heald, Robert, Jackson, Philip, La, Hank, Lainchbury, Michael, Malek, Shiva, Mann, Sam E., Purkey, Hans E., Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen, Sideris, Steve, Wang, Shumei, Yen, Ivana, Yu, Christine, Heffron, Timothy P.
Publicado no ACS Med Chem Lett (2015)

Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation

Por Hanan, Emily J., Eigenbrot, Charles, Bryan, Marian C., Burdick, Daniel J., Chan, Bryan K., Chen, Yuan, Dotson, Jennafer, Heald, Robert A., Jackson, Philip S., La, Hank, Lainchbury, Michael D., Malek, Shiva, Purkey, Hans E., Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M., Sideris, Steve, Tam, Christine, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yin, Jianping, Yu, Christine, Zilberleyb, Inna, Heffron, Timothy P.
Publicado no J Med Chem (2014)