Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma

nork Purkey, Hans E., Dorrell, Michael I., Kelly, Jeffery W.
Argitaratua 2001

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation

nork Peterson, Scott A., Klabunde, Thomas, Lashuel, Hilal A., Purkey, Hans, Sacchettini, James C., Kelly, Jeffrey W.
Argitaratua 1998

Structural analysis of caspase-1 inhibitors derived from Tethering

nork O’Brien, Tom, Fahr, Bruce T., Sopko, Michelle M., Lam, Joni W., Waal, Nathan D., Raimundo, Brian C., Purkey, Hans E., Pham, Phuongly, Romanowski, Michael J.
Argitaratua 2005

Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity

nork Crawford, James J., Lee, Wendy, Johnson, Adam R., Delatorre, Kelly J., Chen, Jacob, Eigenbrot, Charles, Heidmann, Julia, Kakiuchi-Kiyota, Satoko, Katewa, Arna, Kiefer, James R., Liu, Lichuan, Lubach, Joseph W., Misner, Dinah, Purkey, Hans, Reif, Karin, Vogt, Jennifer, Wong, Harvey, Yu, Christine, Young, Wendy B.
Argitaratua izan da ACS Med Chem Lett (2020)

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR

nork Bryan, Marian C., Burdick, Daniel J., Chan, Bryan K., Chen, Yuan, Clausen, Saundra, Dotson, Jennafer, Eigenbrot, Charles, Elliott, Richard, Hanan, Emily J., Heald, Robert, Jackson, Philip, La, Hank, Lainchbury, Michael, Malek, Shiva, Mann, Sam E., Purkey, Hans E., Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen, Sideris, Steve, Wang, Shumei, Yen, Ivana, Yu, Christine, Heffron, Timothy P.
Argitaratua izan da ACS Med Chem Lett (2015)

Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA

nork Alexander, Mary Kate, Miu, Anh, Oh, Angela, Reichelt, Mike, Ho, Hoangdung, Chalouni, Cecile, Labadie, Sharada, Wang, Lan, Liang, Jun, Nickerson, Nicholas N., Hu, Huiyong, Yu, Lan, Du, Miaofen, Yan, Donghong, Park, Summer, Kim, Janice, Xu, Min, Sellers, Benjamin D., Purkey, Hans E., Skelton, Nicholas J., Koehler, Michael F. T., Payandeh, Jian, Verma, Vishal, Xu, Yiming, Koth, Christopher M., Nishiyama, Mireille
Argitaratua izan da Antimicrob Agents Chemother (2018)

Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation

nork Hanan, Emily J., Eigenbrot, Charles, Bryan, Marian C., Burdick, Daniel J., Chan, Bryan K., Chen, Yuan, Dotson, Jennafer, Heald, Robert A., Jackson, Philip S., La, Hank, Lainchbury, Michael D., Malek, Shiva, Purkey, Hans E., Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M., Sideris, Steve, Tam, Christine, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yin, Jianping, Yu, Christine, Zilberleyb, Inna, Heffron, Timothy P.
Argitaratua izan da J Med Chem (2014)

Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice

nork Purkey, Hans E., Robarge, Kirk, Chen, Jinhua, Chen, Zhongguo, Corson, Laura B., Ding, Charles Z., DiPasquale, Antonio G., Dragovich, Peter S., Eigenbrot, Charles, Evangelista, Marie, Fauber, Benjamin P., Gao, Zhenting, Ge, Hongxiu, Hitz, Anna, Ho, Qunh, Labadie, Sharada S., Lai, Kwong Wah, Liu, Wenfeng, Liu, Yajing, Li, Chiho, Ma, Shuguang, Malek, Shiva, O’Brien, Thomas, Pang, Jodie, Peterson, David, Salphati, Laurent, Sideris, Steve, Ultsch, Mark, Wei, BinQing, Yen, Ivana, Yue, Qin, Zhang, Huihui, Zhou, Aihe
Argitaratua izan da ACS Med Chem Lett (2016)

Discovery of a Potent and Selective BCL-X(L) Inhibitor with in Vivo Activity

nork Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M., Park, Chang H., Boghaert, Erwin R., Catron, Nathaniel D., Chen, Jun, Colman, Peter M., Czabotar, Peter E., Deshayes, Kurt, Fairbrother, Wayne J., Flygare, John A., Hymowitz, Sarah G., Jin, Sha, Judge, Russell A., Koehler, Michael F. T., Kovar, Peter J., Lessene, Guillaume, Mitten, Michael J., Ndubaku, Chudi O., Nimmer, Paul, Purkey, Hans E., Oleksijew, Anatol, Phillips, Darren C., Sleebs, Brad E., Smith, Brian J., Smith, Morey L., Tahir, Stephen K., Watson, Keith G., Xiao, Yu, Xue, John, Zhang, Haichao, Zobel, Kerry, Rosenberg, Saul H., Tse, Chris, Leverson, Joel D., Elmore, Steven W., Souers, Andrew J.
Argitaratua 2014