Discovery of a Potent and Selective BCL-X(L) Inhibitor with in Vivo Activity

[Image: see text] A-1155463, a highly potent and selective BCL-X(L) inhibitor, was discovered through nuclear magnetic resonance (NMR) fragment screening and structure-based design. This compound is substantially more potent against BCL-X(L)-dependent cell lines relative to our recently reported inh...

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Detalhes bibliográficos
Main Authors: Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M., Park, Chang H., Boghaert, Erwin R., Catron, Nathaniel D., Chen, Jun, Colman, Peter M., Czabotar, Peter E., Deshayes, Kurt, Fairbrother, Wayne J., Flygare, John A., Hymowitz, Sarah G., Jin, Sha, Judge, Russell A., Koehler, Michael F. T., Kovar, Peter J., Lessene, Guillaume, Mitten, Michael J., Ndubaku, Chudi O., Nimmer, Paul, Purkey, Hans E., Oleksijew, Anatol, Phillips, Darren C., Sleebs, Brad E., Smith, Brian J., Smith, Morey L., Tahir, Stephen K., Watson, Keith G., Xiao, Yu, Xue, John, Zhang, Haichao, Zobel, Kerry, Rosenberg, Saul H., Tse, Chris, Leverson, Joel D., Elmore, Steven W., Souers, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190639/
https://ncbi.nlm.nih.gov/pubmed/25313317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5001867
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