Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

Antagonists of anti-apoptotic Bcl-2 family members hold promise as cancer therapeutics. Apoptosis is triggered when a peptide containing a BH3 motif or a small molecule BH3 peptidomimetic, such as ABT 737, binds to the relevant Bcl-2 family members. ABT-737 is an antagonist of Bcl-2, Bcl-x(L), and B...

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Main Authors: Lee, Erinna F., Czabotar, Peter E., Yang, Hong, Sleebs, Brad E., Lessene, Guillaume, Colman, Peter M., Smith, Brian J., Fairlie, W. Douglas
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2009
主題:
Protein Structure and Folding
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781605/
https://ncbi.nlm.nih.gov/pubmed/19726685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.040725
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