Novel Bcl-2 Homology-3 Domain-like Sequences Identified from Screening Randomized Peptide Libraries for Inhibitors of the Pro-survival Bcl-2 Proteins

Interactions between Bcl-2 homology-3 (BH3)-only proteins and their pro-survival Bcl-2 family binding partners initiate the intrinsic apoptosis pathway. These interactions are mediated by a short helical motif, the BH3 domain, on the BH3-only protein, which inserts into a hydrophobic groove on the p...

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Detalhes bibliográficos
Main Authors: Lee, Erinna F., Fedorova, Anna, Zobel, Kerry, Boyle, Michelle J., Yang, Hong, Perugini, Matthew A., Colman, Peter M., Huang, David C. S., Deshayes, Kurt, Fairlie, W. Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781529/
https://ncbi.nlm.nih.gov/pubmed/19748896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.048009
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