The Functional Differences between Pro-survival and Pro-apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (BH3) Domains

Bcl-2 homology 3 (BH3) domains are short sequence motifs that mediate nearly all protein-protein interactions between B cell lymphoma 2 (Bcl-2) family proteins in the intrinsic apoptotic cell death pathway. These sequences are found on both pro-survival and pro-apoptotic members, although their prim...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lee, Erinna F., Dewson, Grant, Evangelista, Marco, Pettikiriarachchi, Anne, Gold, Grace J., Zhu, Haoran, Colman, Peter M., Fairlie, W. Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4276867/
https://ncbi.nlm.nih.gov/pubmed/25371206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.610758
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