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Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma

Transthyretin (TTR) tetramer dissociation and misfolding facilitate assembly into amyloid fibrils that putatively cause senile systemic amyloidosis and familial amyloid polyneuropathy. We have previously discovered more than 50 small molecules that bind to and stabilize tetrameric TTR, inhibiting am...

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Detalles Bibliográficos
Main Authors: Purkey, Hans E., Dorrell, Michael I., Kelly, Jeffery W.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC33253/
https://ncbi.nlm.nih.gov/pubmed/11344299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.091431798
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