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Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma
Transthyretin (TTR) tetramer dissociation and misfolding facilitate assembly into amyloid fibrils that putatively cause senile systemic amyloidosis and familial amyloid polyneuropathy. We have previously discovered more than 50 small molecules that bind to and stabilize tetrameric TTR, inhibiting am...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The National Academy of Sciences
2001
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC33253/ https://ncbi.nlm.nih.gov/pubmed/11344299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.091431798 |
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