Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma
Transthyretin (TTR) tetramer dissociation and misfolding facilitate assembly into amyloid fibrils that putatively cause senile systemic amyloidosis and familial amyloid polyneuropathy. We have previously discovered more than 50 small molecules that bind to and stabilize tetrameric TTR, inhibiting am...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2001
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33253/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11344299/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.091431798 |
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