Inhibiting transthyretin amyloid fibril formation via protein stabilization
Transthyretin (TTR) amyloid fibril formation is observed systemically in familial amyloid polyneuropathy and senile systemic amyloidosis and appears to be the causative agent in these diseases. Herein, we demonstrate conclusively that thyroxine (10.8 μM) inhibits TTR fibril formation efficiently in...
Salvato in:
| Pubblicato in: | Proc Natl Acad Sci U S A |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1996
|
| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26354/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8986762/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.26.15051 |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|